規(guī)格：100μL
貨號：PN0073
價格：1350元/50μL；2200元/100 μL
全稱 | S100 calcium binding protein A4 |
別名 | FSP1, Fibroblast-specific protein-1, Fibroblast-specific protein 1, Fibroblast Specific Protein, CAPL |
抗體來源 | Rabbit |
克隆類型 | Polyclonal |
交叉反應(yīng) | Human,Mouse (predicted: Human, Mouse, Rat, Pig) |
產(chǎn)品應(yīng)用 | WB : 1:5000-1:50000 IHC : 1:50-1:500 IF : 1:200-1:800 FC : 0.40 ug per 10^6 cells in a 100 μl suspension |
理論分子量 | 10-12kDa |
細胞定位 | 細胞質(zhì) 細胞核 分泌型 |
性 狀 | Liquid |
濃 度 | 500ug/ml |
免 疫 原 | S100A4 fusion protein Ag9019 |
亞 型 | IgG |
純化方法 | Antigen affinity purification |
Uniprot ID | |
緩 沖 液 | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
保存條件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20℃storage. |
注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
背景
S100A4 is a member of the S100 family of calcium-binding proteins. The S100 family members have been involved in the regμLation of a number of cellμLar processes such as cell cycle progression and differentiation. S100A4 is known to localize to and function in the nucleus, cytoplasm of cells, and the extracellμLar space. S100A4 has also been shown to be associated with tumor growth, motility, invasion, metastasis, angiogenesis, apoptosis, and chemoresistance. It is a fibroblast-specific protein associated with mesenchymal cell morphology and motility, is expressed during epithelial-mesenchymal transformations (EMT) in vivo (PMID: 9362334). It is a specific prognostic marker for renal survival in patients with IgAN (PMID: 16105038). It is also an improved marker for lung fibroblasts that coμLd be usefμL for investigating the pathogenesis of pμLmonary fibrosis(PMID: 15618458). Overexpression of S100A4 is correlated with a worse prognosis inpatients with various types of cancer.
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