規(guī)格：50μL/100μL
貨號：PN00791
價格：1350元/50μL；2200元/100 μL
全稱 | CD274 molecμLe Human, Mouse, Pig, Rat(predicted: Human, Mouse, Rat) |
別名 | B7 H, B7 H1, B7 homolog 1, B7H1, CD274, CD274 molecμLe, PD L1, PDCD1 ligand 1, PDCD1L1, PDCD1LG1, PDL1, PD-L1, PD-L1/CD274, Programmed death ligan |
抗體來源/類型 | Mouse Polyclonal |
交叉反應 | Human, Mouse, Pig, Rat(predicted: Human, Mouse, Rat) |
產品應用 | WB : 1:2000-1:10000 IHC : 1:5000-1:20000 IF : 1:50-1:500 FC : 0.20 ug per 10^6 cells in a 100 μl suspension |
理論分子量 | 33kDa |
細胞定位 | 細胞膜 |
性 狀 | Liquid |
濃 度 | 2000ug/ml |
免 疫 原 | PD-L1/CD274 fusion protein Ag12443 |
亞 型 | IgG |
純化方法 | Protein A purification |
Uniprot ID | |
緩 沖 液 | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
保存條件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20℃storage. |
注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
背景
PD-L1, also known as CD274 or B7H1, stands for programmed cell death ligand 1. It is a type I transmembrane protein that is thought to repress immune responses by binding to its receptor (PD1), thus inhibiting T-cell activation, proliferation, and cytokine production. It contains V-like and C-like immunoglobμLin domains. PD-L1 expression is regμLated by various cytokines, such as TNF-α or LPS (ISSN: 1848-7718). Increased expression of this protein in certain types of cancers, e.g., renal cell carcinoma or colon cancer, correlates with poor prognosis.
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