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神經(jīng)以及神經(jīng)細(xì)胞相關(guān)
神經(jīng)以及神經(jīng)細(xì)胞相關(guān)

Anti -Amyloid beta 1-42 Rabbit pAb

規(guī)格：50μL/100μL

貨號：PN0143

價(jià)格：2500元/50μL；5000元/100 μL

產(chǎn)品特性



全稱

Amyloid-beta precursor protein

別名

ABPP, APP, N-APP, Soluble APP-alpha, S-APP-al, C99, APP-C99, Abeta42, Abeta40, Beta-APP40, C83, APP-C59, Amyloid intracellμLar domain 59, APP-C57, Gamma-CTF(50), C31, App, Aβ40, Aβ42, A beta 40，beta Amyloid 40

抗體來源/類型

Rabbit Polyclonal

交叉反應(yīng)

Mouse, Rat，Human

產(chǎn)品應(yīng)用

IHC-FrFl:Use at an assay dependent concentration.

Dot blot:1:7000

IHC-P:1:1000

理論分子量

100 kDa

細(xì)胞定位

細(xì)胞膜，細(xì)胞質(zhì)

性    狀

Liquid

濃    度

0.848 mg/ml

免 疫 原

The details of the immunogen for this antibody are not available.

亞    型

IgG

純化方法

Protein A purified

 

Uniprot ID

P05067

緩 沖 液

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

保存條件

Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20℃storage.

注意事項(xiàng)

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

背景

Aβ derives from APP via proteolytic cleavage by proteases called α-, β- and γ-secretase. The α-secretase cleavage precludes the formation of Aβ, while the β- and γ-cleavages generate APP components with amyloidogenic features. Amyloid beta A4 precursor protein(APP), encoded by APP gene which locate on human chromosome 21q, is a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. APP expressed in all fetal tissues and is pronounced in brain, kidney, heart and spleen, but weak in liver. Defects in APP are the cause of Alzheimer disease type 1 (AD1). Amyloid β (Aβ) precursor protein (APP) is a 100-140 kDa transmembrane glycoprotein that exists as several isoforms. This antibody can recognize several isoforms of both mature and immature amyloid beta (A4) precursor protein, including APP770, APP677, APP695, APP696, APP733, APP751, APP752, and APP639. APP can be cleaved into several chains, this antibody coμLd recognize fragments C99, Amyloid-beta protein 42, Amyloid-beta protein 40, C83, P3(40), C80, Gamma-secretase C-terminal fragment 59, Gamma-secretase C-terminal fragment 57, Gamma-secretase C-terminal fragment 50, C31.