規(guī)格：50μL/100μL
貨號：PN0212
價格：1350元/50 μL ,2200元/100 μL
全稱 | Tumor necrosis factor receptor superfamily member 11B |
別名 | Osteoclastogenesis inhibitory factor, Tnfrsf11b, Ocif, Opg, PDB5, TR1, TNFRSF11B, OCIF, OPG, PDB5 |
抗體來源 | Rabbit |
克隆類型 | Polyclonal |
交叉反應(yīng) | Mouse, Rat |
產(chǎn)品應(yīng)用 | IHC/IF 1:500-1:1000 |
理論分子量 | 46kDa |
細胞定位 | .分泌型 |
性 狀 | Liquid |
濃 度 | 以具體批次為準 |
免 疫 原 | Recombinant protein corresponding to Human Osteoprotegerin |
亞 型 | IgG |
純化方法 | Affinity purification |
Uniprot ID | |
緩 沖 液 | pH: 7.2，Preservative: 0.01% Sodium azide，Constituents: 59% PBS, 0.05% BSA, 40% Glycerol (glycerin, glycerine) |
保存條件 | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. |
注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
背景
Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.
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