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骨相關(guān)
骨相關(guān)

Anti-Alkaline Phosphatase (ALPL)?Rabbit mAb

規(guī)格:50μL/100μL

貨號(hào):PN0211

價(jià)格:1350元/50 μL ,2200元/100 μL

產(chǎn)品特性



全稱

Alkaline phosphatase, tissue-nonspecific isozyme

別名

ALPL, AP-TNAP, APTNAP, HOPS, TNAP,TNSALP, Alkaline phosphatase liver/bone/kidney, TNALP

抗體來源

Rabbit

克隆類型

Monoclonal

交叉反應(yīng)

Human, Mouse, Rat

產(chǎn)品應(yīng)用

WB1:5000 - 1:30000

IHC-P1:200 - 1:2000

ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.

理論分子量

57kDa

細(xì)胞定位

細(xì)胞膜,GPI錨蛋白,脂質(zhì)錨。        

性    狀

Liquid

濃    度

以具體批次為準(zhǔn)

免 疫 原

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Alkaline Phosphatase (ALPL)

亞    型  

IgG

純化方法

Affinity purification

Uniprot ID

P05186

緩 沖 液

pH: 7.2,Preservative: 0.01% Sodium azide,Constituents: 59% PBS, 0.05% BSA, 40% Glycerol (glycerin, glycerine)

保存條件

Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.

注意事項(xiàng)

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

 

背景

This gene encodes a member of the alkaline phosphatase family of proteins. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particμLar tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. Alternative splicing resμLts in mμLtiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme may play a role in bone mineralization. Mutations in this gene have been linked to hypophosphatasia, a disorder that is characterized by hypercalcemia and skeletal defects.