規(guī)格:50μL/100μL
貨號(hào):PN0211
價(jià)格:1350元/50 μL ,2200元/100 μL
全稱 | Alkaline phosphatase, tissue-nonspecific isozyme |
別名 | ALPL, AP-TNAP, APTNAP, HOPS, TNAP,TNSALP, Alkaline phosphatase liver/bone/kidney, TNALP |
抗體來源 | Rabbit |
克隆類型 | Monoclonal |
交叉反應(yīng) | Human, Mouse, Rat |
產(chǎn)品應(yīng)用 | WB1:5000 - 1:30000 IHC-P1:200 - 1:2000 ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements. |
理論分子量 | 57kDa |
細(xì)胞定位 | 細(xì)胞膜,GPI錨蛋白,脂質(zhì)錨。 |
性 狀 | Liquid |
濃 度 | 以具體批次為準(zhǔn) |
免 疫 原 | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Alkaline Phosphatase (ALPL) |
亞 型 | IgG |
純化方法 | Affinity purification |
Uniprot ID | |
緩 沖 液 | pH: 7.2,Preservative: 0.01% Sodium azide,Constituents: 59% PBS, 0.05% BSA, 40% Glycerol (glycerin, glycerine) |
保存條件 | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. |
注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
背景
This gene encodes a member of the alkaline phosphatase family of proteins. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particμLar tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. Alternative splicing resμLts in mμLtiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme may play a role in bone mineralization. Mutations in this gene have been linked to hypophosphatasia, a disorder that is characterized by hypercalcemia and skeletal defects.