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凋亡
凋亡

Anti-Bcl-2 Rabbit mAb

規(guī)格：PN0070-50 μL/100 μL

貨號(hào)：PN0070-50 μL/100 μL

價(jià)格：1350元/50 μL、2000元/100 μL

產(chǎn)品特性



抗體來源

Rabbit

克隆類型

Monoclonal

交叉反應(yīng)

Human,Mouse

產(chǎn)品應(yīng)用

WB 1:1000-1:2000

IHC 1:100-1:200

ICC/IF 1:50-1:200

IHF 1:50-1:200

FC 1:20-1:100

理論分子量

26kDa

細(xì)胞定位

細(xì)胞質(zhì)

性    狀

Liquid

濃    度


免 疫 原

A synthesized peptide derived from human Bcl-2

亞    型

IgG

純化方法

Affinity-chromatography

Uniprot ID

P10415

緩 沖 液

 pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

保存條件

Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle

注意事項(xiàng)

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

 

背景

Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells . RegμLates cell death by controlling the mitochondrial membrane permeability . Appears to function in a feedback loop system with caspases . Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) . Also acts as an inhibitor of autophagy: interacts with BECN1 and AMBRA1 during non-starvation conditions and inhibits their autophagy function . May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release.