規(guī)格：50μL/100μL
貨號：PN0150
價格：1350元/50μL ， 2200元/100 μL
全名 | Anti-SQSTM1/p62 Rabbit pAb |
別名 | P62/SQSTM1, P62, SQSTM1, Sequestosome-1, Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa |
抗體來源 | Rabbit |
克隆類型 | Polyclonal |
別名 | P62/SQSTM1, P62, SQSTM1, Sequestosome-1, Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa |
交叉反應 | Human(Human, Rabbit, Monkey, Chicken, Zebrafish, Hamster, Goat, Goslings) |
產(chǎn)品應用 | WB : 1:5000-1:50000 IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate IHC : 1:200-1:800 IF/ICC : 1:750-1:3000 FC (INTRA) : 0.40 ug per 10^6 cells in a 100 μl suspension |
理論分子量 | 48kDa /62 kDa |
細胞定位 | 細胞質(zhì)，細胞核 |
性 狀 | Liquid |
濃 度 | 700 ug/ml |
免 疫 原 | P62,SQSTM1 fusion protein Ag13131 |
亞 型 | IgG |
純化方法 | Antigen affinity purification |
Uniprot ID | |
緩 沖 液 | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
保存條件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
背景
The product of SQSTM1 gene, Sequestosome-1, also kown as ubiquitin-binding protein p62, is an autophagosome cargo protein that targets other proteins that bind to it for selective autophagy. By interacting with GATA4 and targeting it for degradation, it can inhibit GATA-4 associated senescence and senescence-associated secretory phenotype.
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