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Anti-Beclin 1 Rabbit pAb

Anti-Beclin 1 Rabbit pAb

規(guī)格：50μL/100μL

貨號：PN0149

價格：1350-50 μL， 2200元/100 μL

產(chǎn)品特性

1746606367160578.pngBeclin 1 一抗-產(chǎn)品說明書1.pdf



全名

Anti-Beclin 1 Rabbit pAb

別名

Coiled-coil myosin-like BCL2-interacting protein, Protein GT197, BECN1, GT197, APG6, VPS30, Protein GT197, beclin1, beclin-1

抗體來源

Rabbit

克隆類型

Polyclonal

別名

Coiled-coil myosin-like BCL2-interacting protein, Protein GT197, BECN1, GT197, APG6, VPS30, Protein GT197, beclin1, beclin-1

交叉反應(yīng)

Human,mouse，Rat (predicted: ,Pig, Chicken, Zebrafish, Hamster, Goat, Fish, Duck)

產(chǎn)品應(yīng)用

WB：    1:1000-10000,

IP：     0.5-4.0 ug for 1.0-3.0 mg of total protein lysate

IHC-P：  1:50-500,

IF-P：    1:50-500,

IF-FRO：  1:50-500,

IF/ICC :   1:200-1:800

理論/實際分子量

52kDa /52~60 kDa

細(xì)胞定位

細(xì)胞質(zhì)，細(xì)胞核

性    狀

Liquid

濃    度

600ug/ml 

免 疫 原

Beclin 1 fusion protein Ag1843

亞    型

IgG  

純化方法

Antigen affinity purification

Uniprot ID

Q14457

緩 沖 液

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

保存條件

Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

注意事項

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

背景

Beclin 1, also known as ATG6 or VPS30, interacts with various cofactors (e.g. Ambra1, Barkor (Atg14), Rubicon, or UVRAG) to regulate the lipid kinase Vps34 and promote the formation of the BECLIN1-Vps34-Vps15 complex, hence inducing autophagy. Its function (via the BH3 domain) is inhibited by Bcl-2 or Bcl-XL. Beclin 1 (BECN1) is a crucial molecule in the control of the autophagic activity, and its activity is regulated by multiple mechanisms, including the post-translational modification, protein-protein interaction, and subcellular localization. It plays a role in crosstalk between apoptosis and autophagy. It has been reported that Beclin 1 can be cleaved into fragments of 50, 37 and 35 kDa during apoptosis. It is involved in many disorders, including neurodegeneration and cancer (tumorigenesis). Beclin 1 is a mammalian tumor suppressor, and its gene is monoallelically deleted in 75% of ovarian, 50% of breast, and 40% of prostate cancers. Decreased expression of Beclin 1 has also been observed in human brain and lung tumors. The level of Beclin 1 was decreased in the affected brain regions of patients with Alzheimer's disease early in the disease process. Recent studies have also shown that gain and loss of Beclin 1 function affects the death of heart cells.