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腫瘤標(biāo)記物
腫瘤標(biāo)記物

Anti- PCNA Rabbit pAb

規(guī)格：50μL/100μL

貨號(hào)：PN0132

價(jià)格：1350元/50μL；2200元/100 μL

產(chǎn)品特性



全稱

PCNA Polyclonal antibody

別名

PCNA

 

抗體來(lái)源

Rabbit

克隆類型

Polyclonal

交叉反應(yīng)

 Mouse, Rat, Human(predicted: Human, Mouse, Rat,Goat ,Chicken,Medaka Embryos,Sheep, Ducks, Rabbit)

產(chǎn)品應(yīng)用

WB：1:5000-1:50000

IHC：1:1500-1:6000

IF-P： 1：50-500

IF/ICC:1:300-1200

IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate

理論分子量

50kDa

細(xì)胞定位

細(xì)胞核

性    狀

Liquid

濃    度

 550 ug/ml

免 疫 原


亞    型

IgG

純化方法

Antigen affinity purification

Uniprot ID

P12004

緩 沖 液

pH: 7.2,Preservative: 0.01% Sodium azide,Constituents: PBS, 40% Glycerol, 0.05% BSA

保存條件

Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.

注意事項(xiàng)

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

 

背景

Proliferating Cell Nuclear Antigen, commonly known as PCNA, is a protein that acts as a processivity factor for DNA polymerase δ in eukaryotic cells. This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. PCNA induces a robust stimμLatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. It has to be loaded onto DNA in order to be able to stimμLate APEX2. PCNA protein is highly conserved during evolution; the deduced amino acid sequences of rat and human differ by only 4 of 261 amino acids. PCNA has been used as loading control for proliferating cells. This antibody is a rabbit polyclonal antibody raised against an internal region of human PCNA. The calcμLated molecμLar weight of PCNA is 29 kDa, but modified PCNA is 36kDa