規(guī)格：10μL/40μL
貨號：PN0141
價(jià)格：1350元/50μL；2200元/100 μL
全稱 | Anti-P53/TP53 Antibody |
別名 | Antigen NY CO 13; CellμLar tumor antigen p53; LFS1; P53; Phosphoprotein p53; TP53; TRP53; tumor protein p53; Tumor suppressor p53 |
抗體來源/類型 | Mouse monoclonal |
交叉反應(yīng) | Human |
產(chǎn)品應(yīng)用 | WB ：1:500-2000 IHC：1：50-1：:400 ICC/IF：1：50-1：:400 |
理論/實(shí)際分子量 | 44kDa / 53kDa |
細(xì)胞定位 | 細(xì)胞核，細(xì)胞漿 |
性 狀 | Liquid |
濃 度 | 200ug/ml |
免 疫 原 | Recombinant human wild-type p53 protein. |
亞 型 | IgG |
純化方法 | Ascites |
Uniprot ID | |
緩 沖 液 | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
保存條件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessaryfor -20℃storage. |
注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
背景
The p53 tumor antigen is found in increased amounts in a wide variety of transformed cells. The protein is also detectable in many actively proliferating, nontransformed cells, but it is undetectable or present at low levels in resting cells. This protein induces cell cycle arrest or apoptosis in response to sublethal or severe DNA damage, respectively, by differential transcription of target genes and through transcription-independent apoptotic functions. The p53 protein contains 393 amino acids. Human p53 tumour antigen is Locatedto band 17p13. p53 mutations are common in pancreatic cancer and are absent in chronic pancreatitis.
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