規(guī)格:50μL/100μL
貨號(hào):PN0118
價(jià)格:1350元/50μL,2200元/100 μL
全稱 | Tumor necrosis factor alpha |
別名 | TNF,DIF,TNF-alpha,TNFA,TNFSF2,Tumour necrosis factor, Tumour necrosis factor alpha,tumor necrosis factor, TNLG1, TNF-α, TNF a, TNF alpha,NFα, TNF-α, Cachectin, TNFα.
|
抗體來源 | Rabbit |
克隆類型 | Polyclonal |
交叉反應(yīng) | Mouse, Rat |
產(chǎn)品應(yīng)用 | WB: 1: 200-1: 500IHC/IF: 1: 200-1: 800
|
理論分子量 | 26kDa |
細(xì)胞定位 | 細(xì)胞膜,分泌型蛋白 |
性 狀 | Liquid |
濃 度 | 批次間有差異 |
免 疫 原 | KLH conjugated Synthetic peptide corresponding to Mouse TNF-alpha |
亞 型 | IgG |
純化方法 | Affinity purification |
Uniprot ID | |
緩 沖 液 | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
保存條件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
背景
TNF, as also known as TNF-alpha, or cachectin, is a mμLtifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. It is expressed as a 26 kDa membrane bound protein and is then cleaved by TNF-alpha converting enzyme (TACE) to release the soluble 17 kDa monomer, which forms homotrimers in circμLation. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR.