規(guī)格：50μL/100μL
貨號：PN0120
價格：1350元/50μL，2200元/100 μL
全稱 | Rabbit Anti-IL-10 antibody |
別名 | Interleukin-10 precursor; Cytokine synthesis inhibitory factor; CSIF; Cytokine Synthesis Inhibitory Factor; IL 10; IL10A; Interleukin 10; Interleukin10; MGC126450; MGC126451; TGIF; IL10_HUMAN. |
抗體來源 | Rabbit |
克隆類型 | Polyclonal |
交叉反應(yīng) | Human, Mouse (predicted: Rat, Rabbit, Pig, Sheep, Chicken, GuineaPig) |
產(chǎn)品應(yīng)用 | WB=1:500-2000IHC-P=1:100-500IHC-F=1:100-500IF=1:100-500
|
理論分子量 | 18kDa |
細胞定位 | 分泌型 |
性 狀 | Liquid |
濃 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human IL-10 |
亞 型 | IgG |
純化方法 | affinity purified by Protein A |
Uniprot ID | |
緩 沖 液 | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
保存條件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
背景
The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregμLation and inflammation. It down-regμLates the expression of Th1 cytokines, MHC class II Ags, and costimμLatory molecμLes on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regμLation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregμLator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.
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