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細(xì)胞殺傷相關(guān)
細(xì)胞殺傷相關(guān)

Anti- PD1 /CD279 Mouse mAb

規(guī)格：50μL/100μL

貨號(hào)：PN0078

價(jià)格：1350元/50μL；2200元/100 μL

產(chǎn)品特性



全稱

programmed cell death 1

別名

CD279, hPD 1, hPD l, PD1, PD-1, PD-1/CD279, PDCD1, programmed cell death 1, Protein PD 1, SLEB2

抗體來源

Mouse

克隆類型

Monoclonal 

交叉反應(yīng)

Human, Rat, Mouse, Pig (predicted: Human, Mouse, Rat)

產(chǎn)品應(yīng)用

WB : 1:5000-1:50000

IHC : 1:2000-1:8000

IF : 1:200-1:800

FC : 0.20 ug per 10^6 cells in a 100 μl suspension

理論分子量

32kDa

細(xì)胞定位

細(xì)胞膜

性    狀

Liquid

濃    度

1213ug/ml

免 疫 原

PD-1/CD279 fusion protein Ag12470 

亞    型

IgG

純化方法

Protein A purification 

Uniprot ID

Q15116

緩 沖 液

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

保存條件

Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20℃storage.

注意事項(xiàng)

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

 

背景

Programmed cell death 1 (PD-1, also known as CD279) is an immunoinhibitory receptor that belongs to the CD28/CTLA-4 subfamily of the Ig superfamily. It is a 288 amino acid (aa) type I transmembrane protein composed of one Ig superfamily domain, a stalk, a transmembrane domain, and an intracellμLar domain containing an immunoreceptor tyrosine-based inhibitory motif (ITIM) as well as an immunoreceptor tyrosine-based switch motif (ITSM) (PMID: 18173375). PD-1 is expressed during thymic development and is induced in a variety of hematopoietic cells in the periphery by antigen receptor signaling and cytokines (PMID: 20636820). Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function (PMID: 19426218). It is critical for the regμLation of T cell function during immunity and tolerance. Blockade of PD-1 can overcome immune resistance and also has been shown to have antitumor activity (PMID: 22658127; 23169436). The calcμLated molecμLar weight of PD-1 is 32 kDa. It has been reported that PD-1 is heavily glycosylated and migrates with an apparent molecμLar mass of 47-55 kDa on SDS-PAGE (PMID: 8671665; 17640856; 17003438).