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細(xì)胞骨架
細(xì)胞骨架

Anti-Beta Catenin Rabbit pAb

規(guī)格：50μL/100μL

貨號(hào)：PN0202

價(jià)格：1350元/50μL；2200元/100 μL

產(chǎn)品特性



全稱

Beta Catenin

別名

b cat, B-catenin, beta-Catenin, Catenin beta 1, Catenin beta-1

抗體來源

Rabbit

克隆類型

Polyclonal

交叉反應(yīng)

Human, Mouse, Rat, Pig

產(chǎn)品應(yīng)用

WB : 1:5000-1:50000

IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate

IHC : 1:1000-1:4000

IF-P : 1:500-1:2000

IF/ICC : 1:50-1:500

FC (INTRA) : 0.20 ug per 10^6 cells in a 100 μl suspens

理論/實(shí)際分子量

781 aa, 86 kDa/92 kDa

細(xì)胞定位

細(xì)胞質(zhì) 細(xì)胞核 細(xì)胞膜  細(xì)胞連接

性    狀

Liquid

濃    度

 500 ug/ml

免 疫 原

Peptide1

 

亞    型

IgG

純化方法

Affinity-chromatography

Uniprot ID

P35222

緩 沖 液

Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

保存條件

Store at +4°C for short term. Store at -20°C for long term. Avoid freeze/thaw cycle.

注意事項(xiàng)

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

 

背景

    β-Catenin, also known as CTNNB1, is an evolutionarily conserved, mμLtifunctional intracellμLar protein. β-Catenin is a 92-kDa protein, originally identified in cell adherens junctions (AJs) where it functions to bridge the cytoplasmic domain of cadherins to a-catenin and the actin cytoskeleton. Besides its essential role in the AJs, β-catenin is also a key downstream component of the canonical Wnt pathway that plays diverse and critical roles in embryonic development and adμLt tissue homeostasis. The Wnt/β-catenin pathway is also involved in the activation of other intracellμLar messengers such as calcium fluxes, JNK, and SRC kinases. DeregμLation of β-catenin activity is associated with mμLtiple diseases including cancers.