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鐵死亡
鐵死亡

Anti-SLC7A11/XCT Rabbit pAb

規(guī)格：50μL/100μL

貨號(hào)：PN0075

價(jià)格：1350元/50μL、2200元/100 μL

產(chǎn)品特性



全稱

solute carrier family 7, (cationic amino acid transporter, y+ system)

 member 11

別名

Amino acid transport system xc, CCBR1, Cystine/glutamate transporter,

SLC7A11, SLC7A11/xCT, xCT

抗體來源

Rabbit

克隆類型

Polyclonal

交叉反應(yīng)

Human(predicted: Human, Goat, Chicken)

產(chǎn)品應(yīng)用

WB : 1:500-1:2000 

IHC : 1:50-1:500 

IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate

FC : 0.80 ug per 10^6 cells in a 100 μl suspension

理論分子量

55kDa

細(xì)胞定位

細(xì)胞膜

性    狀

Liquid

濃    度

500ug/ml 

免 疫 原

SLC7A11/xCT fusion protein Ag25431 

亞    型

IgG

純化方法

affinity purified by Protein A

Uniprot ID

Q9UPY5

緩 沖 液

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

保存條件

Store at -20°C. Stable for one year after shipment. 

注意事項(xiàng)

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

 

背景

SLC7A11 (also known as xCT) is a membrane transporter involved in the uptake of cystine. It promotes glutathione synthesis through the uptake of cystine and the concomitant release of glutamate. This, in turn, protects cells from oxidative stress, maintains cellμLar redox balance, and prevents cell death induced by lipid peroxidation. SLC7A11 has been identified as a potential target for cancer therapeutics. It is overexpressed in mμLtiple malignant tumors and is closely associated with the growth, prognosis, metastasis, and treatment response of various cancers including lung cancer. 26864-1-AP recognizes the 55 kDa and 35-40 kDa protein similar to the paper published (PMID: 32188872, 19156441).