規(guī)格：50μL/100μL
貨號：PN0181
價格：1350元/50μL；2200元/100 μL
全稱 | protein tyrosine phosphatase, receptor type, C |
別名 | B220, EC:3.1.3.48, GP180, L CA, LCA |
抗體來源 | Rabbit |
克隆類型 | Polyclonal |
交叉反應 | Human, Mouse, Rat, Pig, Canine, Bovine, Sheep |
產(chǎn)品應用 | WB : 1:5000-1:50000 IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate IHC : 1:1000-1:6000 IF-P : 1:50-1:500 IF-FRO : 1:200-1:800 IF/ICC : 1:50-1:500 |
理論分子量 | 1304 aa, 147 kDa |
細胞定位 | 細胞膜 |
性 狀 | Liquid |
濃 度 | 700 ug/ml |
免 疫 原 | CD45 fusion protein Ag13712 |
亞 型 | IgG |
純化方法 | Antigen affinity purification |
Uniprot ID | |
緩 沖 液 | pH: 7.2，Preservative: 0.01% Sodium azide，Constituents: PBS, 40% Glycerol, 0.05% BSA |
保存條件 | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. |
注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
背景
Protein tyrosine phosphatase receptor type C (PTPRC) is also known as CD45 antigen, which was originally called leukocyte common antigen (LCA). CD45 is an enzyme required for T-cell activation through the antigen receptor consisting of two intracellμLar phosphatase domains, a transmembrane domain and an extracellμLar domain. Upon T-cell activation, CD45 recruits and dephosphorylates SKAP1 via an interaction through the first PTPase domain, which is the only domain to possess intrinsic kinase activity. However, both domains are required for appropriate phosphatase and T-cell antigen receptor activity
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