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巨噬細胞
巨噬細胞

Anti- inos Rabbit pAb

規(guī)格：50μL/100μL

貨號：PN0203

價格：1350元/50μL；2200元/100 μL

產(chǎn)品特性



全稱

nitric oxide synthase 2, inducible

別名

NOS2, EC:1.14.13.39, Hepatocyte NOS, HEP-NOS, Inducible NO synthase

抗體來源

Rabbit

克隆類型

Polyclonal

交叉反應(yīng)

Human, Mouse, Rat, Pig, Chicken, Bovine

產(chǎn)品應(yīng)用

WB : 1:500-1:4000

IF/ICC : 1:50-1:500

FC (INTRA) : 0.40 ug per 10^6 cells in a 100 μl suspensi

理論分子量

131kDa

細胞定位

細胞質(zhì)

性    狀

Liquid

濃    度

900 ug/ml

免 疫 原

Peptide

亞    型

IgG

純化方法

Antigen affinity purification

Uniprot ID

P35228

緩 沖 液

pH: 7.2，Preservative: 0.01% Sodium azide，Constituents: PBS, 40% Glycerol, 0.05% BSA

保存條件

Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.

注意事項

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

背景

NOS2, also named as iNOS and NOS2A, produces nitric oxide (NO) which is a messenger molecμLe with diverse functions throughout the body. NO is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission, antimicrobial and antitumoral activities. NOS2 is a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. iNOS has a very short half-life due to rapid degradation by calpain. iNOS monomer is a direct substrate of calpain I and can be cleaved by calpain I at the canonical CaM-binding site(503-532aa) of iNOS, and then a ~70 kDa band can be detected by western (PMID:11786228). This antibody is specific to NOS2.